Long-lasting reduction of Brugia timori microfilariae following a single dose of diethylcarbamazine combined with albendazole.
Identifieur interne : 012C51 ( Main/Exploration ); précédent : 012C50; suivant : 012C52Long-lasting reduction of Brugia timori microfilariae following a single dose of diethylcarbamazine combined with albendazole.
Auteurs : Peter Fischer [Allemagne] ; Yenny Djuardi ; Is S. Ismid ; Paul Rückert ; Mark Bradley ; Taniawati SupaliSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ]
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Albendazole (usage thérapeutique), Animaux, Association médicamenteuse, Brugia, Diéthylcarbamazine (usage thérapeutique), Enfant, Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Humains, Mâle, Résultat thérapeutique, Sujet âgé, Études de suivi.
- MESH :
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Albendazole, Diéthylcarbamazine, Filaricides.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Association médicamenteuse, Brugia, Enfant, Femelle, Humains, Mâle, Résultat thérapeutique, Sujet âgé, Études de suivi.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Albendazole, Diethylcarbamazine, Filaricides.
- drug therapy : Elephantiasis, Filarial.
- Adolescent, Adult, Aged, Animals, Brugia, Child, Drug Combinations, Female, Follow-Up Studies, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
The long-term effect of a single oral dose of 6 mg/kg bodyweight of diethylcarbamazine (DEC) combined with 400 mg albendazole (ALB) on the microfilariae (mf) of the lymphatic filarial parasite Brugia timori was studied on Alor island, Indonesia from April 2001 to April 2002. Before treatment the geometric mean of the mf density in 96 infected study subjects was 150 mf/mL night blood (range 1-5696 mf/mL). One year after treatment 69 subjects (72%) were mf-negative and the overall geometric mean mf density reduced to 3 mf/mL (0-2456 mf/mL). The reduction of mf was more pronounced 1 year after treatment compared with 6 months after treatment. It can be concluded that a single dose of DEC + ALB leads to a long-term and progressive suppression of B. timori mf for at least 1 year. Therefore, DEC+ ALB can be recommended as an effective strategy to control B. timori infection in the framework of the Global Programme to Eliminate Lymphatic Filariasis.
PubMed: 15259479
Affiliations:
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Ismid</name></author><author><name sortKey="Ruckert, Paul" sort="Ruckert, Paul" uniqKey="Ruckert P" first="Paul" last="Rückert">Paul Rückert</name></author><author><name sortKey="Bradley, Mark" sort="Bradley, Mark" uniqKey="Bradley M" first="Mark" last="Bradley">Mark Bradley</name></author><author><name sortKey="Supali, Taniawati" sort="Supali, Taniawati" uniqKey="Supali T" first="Taniawati" last="Supali">Taniawati Supali</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2003 Jul-Aug</MedlineDate></PubDate></date><idno type="RBID">pubmed:15259479</idno><idno type="pmid">15259479</idno><idno type="wicri:Area/PubMed/Corpus">003F51</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003F51</idno><idno type="wicri:Area/PubMed/Curation">003F51</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003F51</idno><idno type="wicri:Area/PubMed/Checkpoint">003F51</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003F51</idno><idno type="wicri:Area/Ncbi/Merge">001A68</idno><idno type="wicri:Area/Ncbi/Curation">001A68</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A68</idno><idno type="wicri:doubleKey">0035-9203::Fischer P:long:lasting:reduction</idno><idno type="wicri:Area/Main/Merge">013E70</idno><idno type="wicri:Area/Main/Curation">012C51</idno><idno type="wicri:Area/Main/Exploration">012C51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-lasting reduction of Brugia timori microfilariae following a single dose of diethylcarbamazine combined with albendazole.</title><author><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name><affiliation wicri:level="3"><nlm:affiliation>Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. pfischer@bni-hamburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Djuardi, Yenny" sort="Djuardi, Yenny" uniqKey="Djuardi Y" first="Yenny" last="Djuardi">Yenny Djuardi</name></author><author><name sortKey="Ismid, Is S" sort="Ismid, Is S" uniqKey="Ismid I" first="Is S" last="Ismid">Is S. Ismid</name></author><author><name sortKey="Ruckert, Paul" sort="Ruckert, Paul" uniqKey="Ruckert P" first="Paul" last="Rückert">Paul Rückert</name></author><author><name sortKey="Bradley, Mark" sort="Bradley, Mark" uniqKey="Bradley M" first="Mark" last="Bradley">Mark Bradley</name></author><author><name sortKey="Supali, Taniawati" sort="Supali, Taniawati" uniqKey="Supali T" first="Taniawati" last="Supali">Taniawati Supali</name></author></analytic><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Albendazole (therapeutic use)</term><term>Animals</term><term>Brugia</term><term>Child</term><term>Diethylcarbamazine (therapeutic use)</term><term>Drug Combinations</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Female</term><term>Filaricides (therapeutic use)</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Albendazole (usage thérapeutique)</term><term>Animaux</term><term>Association médicamenteuse</term><term>Brugia</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Enfant</term><term>Femelle</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Albendazole</term><term>Diethylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Albendazole</term><term>Diéthylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Brugia</term><term>Child</term><term>Drug Combinations</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Association médicamenteuse</term><term>Brugia</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The long-term effect of a single oral dose of 6 mg/kg bodyweight of diethylcarbamazine (DEC) combined with 400 mg albendazole (ALB) on the microfilariae (mf) of the lymphatic filarial parasite Brugia timori was studied on Alor island, Indonesia from April 2001 to April 2002. Before treatment the geometric mean of the mf density in 96 infected study subjects was 150 mf/mL night blood (range 1-5696 mf/mL). One year after treatment 69 subjects (72%) were mf-negative and the overall geometric mean mf density reduced to 3 mf/mL (0-2456 mf/mL). The reduction of mf was more pronounced 1 year after treatment compared with 6 months after treatment. It can be concluded that a single dose of DEC + ALB leads to a long-term and progressive suppression of B. timori mf for at least 1 year. Therefore, DEC+ ALB can be recommended as an effective strategy to control B. timori infection in the framework of the Global Programme to Eliminate Lymphatic Filariasis.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><noCountry><name sortKey="Bradley, Mark" sort="Bradley, Mark" uniqKey="Bradley M" first="Mark" last="Bradley">Mark Bradley</name><name sortKey="Djuardi, Yenny" sort="Djuardi, Yenny" uniqKey="Djuardi Y" first="Yenny" last="Djuardi">Yenny Djuardi</name><name sortKey="Ismid, Is S" sort="Ismid, Is S" uniqKey="Ismid I" first="Is S" last="Ismid">Is S. Ismid</name><name sortKey="Ruckert, Paul" sort="Ruckert, Paul" uniqKey="Ruckert P" first="Paul" last="Rückert">Paul Rückert</name><name sortKey="Supali, Taniawati" sort="Supali, Taniawati" uniqKey="Supali T" first="Taniawati" last="Supali">Taniawati Supali</name></noCountry><country name="Allemagne"><region name="Hambourg"><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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